abstract：:To study the pharmacokinetics and pharmacodynamics of two intravenous nizatidine dosing regimens, serial plasma concentrations and continuous intragastric pH were monitored simultaneously in 10 subjects with a documented history of duodenal or gastric ulcers. A 24-hour gastric pH profile was characterized for a 300 mg...

journal_title：Journal of clinical pharmacology

authors： Danziger L,Furmaga KM,Rodvold KA,Bombeck CT,Fischer JH

更新日期：1989-10-01 00:00:00

abstract：:The effects of labetalol, diltiazem and verapamil on antipyrine and indocyanine green clearance were evaluated in a placebo-controlled, repeated measures evaluation. Twelve healthy subjects received either labetalol (200 mg every 12 hours), diltiazem (90 mg. every 8 hours), verapamil (80 mg every 8 hours), or placebo ...

journal_title：Journal of clinical pharmacology

authors： Rocci ML Jr,Vlasses PH,Lener ME,Fruncillo RA,Sirgo MA

更新日期：1989-10-01 00:00:00

abstract：:The effects of long-term triple drug therapy on renal function in patients with moderate to severe essential hypertension have not been evaluated systematically. We prospectively studied fifteen male patients with moderate to severe essential hypertension receiving triple drug therapy (metolazone, atenolol or betaxolo...

journal_title：Journal of clinical pharmacology

authors： Reams GP,Bauer JH

更新日期：1989-09-01 00:00:00

abstract：:The need for clinical pharmacology in research and education, drug development, and health care delivery is well known. However, a current profile of those working in the field is not available. The ACCP authorized a survey of clinical pharmacologists to provide such a profile. Members of the ACCP or ASCPT were solici...

journal_title：Journal of clinical pharmacology

authors： Wilson JT,Brown RD,Kimura KK,Whelton A

更新日期：1989-08-01 00:00:00

abstract：:The centrally acting agents are one of several differing classes of drugs now available for antihypertensive therapy. The availability of newer pharmacologic classes, including the beta-blockers, alpha-blockers. ACE inhibitors and calcium channel blockers, has resulted in a relative decline in the use of the centrally...

journal_title：Journal of clinical pharmacology

authors： Weber MA

更新日期：1989-07-01 00:00:00

abstract：:The influence of the method of cimetidine administration on theophylline disposition was studied in nine healthy, cigarette smoking male volunteers. The treatment phases consisted of: A) theophylline alone, B) theophylline plus intermittent cimetidine therapy (300 mg IV every 6 hr), and C) theophylline in combination ...

journal_title：Journal of clinical pharmacology

authors： Gutfeld MB,Welage LS,Walawander CA,Wilton JH,Harrison NJ

更新日期：1989-07-01 00:00:00

abstract：:Nonlinearities are commonplace in pharmacokinetics and most frequently occur because of a limited concentration of biological material available for interaction with relatively high concentrations of drugs. The Michaelis-Menten-type function can be applied to metabolism, transport, and binding phenomena that display c...

journal_title：Journal of clinical pharmacology

authors： Jusko WJ

更新日期：1989-06-01 00:00:00

abstract：:The effects of propafenone on the pharmacokinetics and pharmacodynamics of propranolol were evaluated in 12 healthy male subjects. Both propafenone and propranolol were each administered alone for one week followed by concomitant administration for an additional week. Blood samples, obtained at steady-state, were anal...

journal_title：Journal of clinical pharmacology

authors： Kowey PR,Kirsten EB,Fu CH,Mason WD

更新日期：1989-06-01 00:00:00

abstract：:Amiodarone is an effective antiarrhythmic drug for the control of potentially lethal and lethal ventricular arrhythmias (VA). In the United States, a high-dose regimen has been used at the expense of a high toxicity profile for the control of lethal VAs. Significant antiarrhythmic efficacy has also been established wi...

journal_title：Journal of clinical pharmacology

authors： Kerin NZ,Aragon E,Faitel K,Frumin H,Rubenfire M

更新日期：1989-05-01 00:00:00

abstract：:The type II histamine receptor antagonists, cimetidine and ranitidine, widely used in treatment of peptic ulcer disease have been reported to cause bradycardia. To evaluate the cardiovascular effects of H2 antagonists nineteen healthy volunteers were entered into a double-blind crossover comparison of cimetidine 300 m...

journal_title：Journal of clinical pharmacology

authors： Hughes DG,Dowling EA,DeMeersman RE,Garnett WR,Karnes HT

更新日期：1989-05-01 00:00:00

abstract：:Using a sensitive and specific radioimmunoassay the pharmacokinetic disposition of clonidine was determined in hypertensive patients after a single dose and then after 5, 28 and 56 days of chronic dosing with 75 micrograms bd. Following a single dose of clonidine maximal plasma concentrations of 0.34 +/- 0.06 ng/ml we...

journal_title：Journal of clinical pharmacology

authors： Anavekar SN,Howes LG,Jarrott B,Syrjanen M,Conway EL,Louis WJ

更新日期：1989-04-01 00:00:00

abstract：:Reduced bioavailability (F) due to hepatic first-pass extraction of an oral dose (D) is a well-known pharmacokinetic phenomenon. An integrated solution for Michaelis-Menten kinetics of the first-pass effect is derived from the maximal metabolic rate (Vm), volume of distribution (Vd), first order absorption rate consta...

journal_title：Journal of clinical pharmacology

authors： Keller F,Kunzendorf U,Walz G,Haller H,Offermann G

更新日期：1989-03-01 00:00:00

abstract：:The effect of desipramine on chronic ventricular ectopic depolarizations (VEDs) was studied in 10 patients with at least 30 VEDs per hour. A single-blind, placebo-controlled, dose-ranging protocol was followed. Efficacy was defined as a decrease in VED frequency of at least 75%, base on three 24 hour ambulatory ECGs o...

journal_title：Journal of clinical pharmacology

authors： Fenster PE,Bressler R,Kipps J

更新日期：1989-02-01 00:00:00

abstract：:The peritoneal clearance of gentamicin was studied in 11 chronic uremic patients who undergoing intermittent peritoneal dialysis. Gentamicin was significantly removed by peritoneal dialysis with a clearance value of 9.75 +/- 3.78 ml/min. The serum half life was 14.08 +/- 3.57 hr, a value significantly less than that o...

journal_title：Journal of clinical pharmacology

authors： Kaojarern S,Arkaravichien W,Indraprasit S,Pummangura C

更新日期：1989-02-01 00:00:00

abstract：:A decrease in dietary protein intake lowers the clearance of a number of substances excreted principally by the kidney including uric acid and oxypurinol, the major metabolite of allopurinol. We studied the kinetics of uric acid and oxypurinol in seven healthy volunteers on a normal protein diet (2600 calories; 100 g ...

journal_title：Journal of clinical pharmacology

authors： Kitt TM,Park GD,Spector R,Tsalikian E

更新日期：1989-01-01 00:00:00

abstract：:In a placebo-controlled, randomized, double-blind cross-over study in 12 healthy volunteers the effect of acute alcohol intake during treatment with transdermally administered scopolamine (TTS-scopolamine) was investigated. One group of six subjects reached maximal blood alcohol concentrations (BAC) of 80 mg/dL and an...

journal_title：Journal of clinical pharmacology

authors： Gleiter CH,Antonin KH,Schoenleber W,Bieck PR

更新日期：1988-12-01 00:00:00

abstract：:Twelve healthy volunteers received single oral doses of propranolol (80 mg), metoprolol (100 mg), L-bunolol (2 mg), and placebo in a four-way crossover study. Blood pressure, ventricular rate, and echocardiographically determined ejection fraction, ejection time, and mean rate of circumferential fiber shortening (mVcf...

journal_title：Journal of clinical pharmacology

authors： Ochs HR,Bahrmann H,Greenblatt DJ,Labedzki L

更新日期：1988-12-01 00:00:00

abstract：:The onset and offset of the electropharmacologic effect of procainamide was studied in nine patients with ventricular arrhythmias. Procainamide was given at a constant infusion rate of 0.27 +/- 0.05 mg/kg/min for 50 to 60 minutes to an average total dose of 15.5 +/- 4.4 mg/kg. The QRS interval (used as an index of ele...

journal_title：Journal of clinical pharmacology

authors： Liem LB,Yee YG,Swerdlow CD,Kates RE

更新日期：1988-11-01 00:00:00

abstract：:Aminoglycosides have become an indispensable component in the armamentarium against serious gram-negative infections. In spite of the availability of effective guidelines for prevention, the frequency of toxic side effects associated with aminoglycoside therapy is an impetus for the substitution of safer and equally e...

journal_title：Journal of clinical pharmacology

authors： Whelton A

更新日期：1988-10-01 00:00:00

abstract：:The frequency of hemodialysis-associated hemorrhage was studied prospectively in two successive, parallel, heparin-controlled studies using epoprostenol (PGI2; average dose, 4.1 ng/kg.min) as the sole antithrombotic agent. Sixty-three patients with active or recently active bleeding underwent 163 hemodialysis treatmen...

journal_title：Journal of clinical pharmacology

authors： Swartz RD,Flamenbaum W,Dubrow A,Hall JC,Crow JW,Cato A

更新日期：1988-09-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of verapamil were investigated in six chronic hemodialysis patients. A single oral 120-mg dose was administered both on a non-hemodialysis day and a hemodialysis day separated by greater than or equal to 7 days. Blood pressure and PR interval were measured simultaneously with ...

journal_title：Journal of clinical pharmacology

authors： Hanyok JJ,Chow MS,Kluger J,Izard MW

更新日期：1988-09-01 00:00:00

abstract：:Monitoring drug levels in patients is standard practice in presentday critical care medicine. Clinical laboratories, however, are often unable to assay drug levels immediately following phlebotomy. This may result in blood samples being kept under a variety of storage conditions for nonuniform periods of time. The cur...

journal_title：Journal of clinical pharmacology

authors： Colucci RD,Halpern NA,Levy E,McElhinney AJ,Greenstein RJ

更新日期：1988-08-01 00:00:00

abstract：:The efficacy and safety of esmolol, a titratable intravenous beta-adrenergic blocking agent with a short elimination half-life (t 1/2 = 9.0 min) was evaluated in a multicenter open-label study for the treatment of supraventricular tachyarrhythmias (heart rate greater than 100 bpm). The study also investigated the feas...

journal_title：Journal of clinical pharmacology

authors： Das G,Tschida V,Gray R,Dhurandhar R,Lester R,McGrew F,Askenazi J,Kaplan K,Emanuele M,Turlapaty P

更新日期：1988-08-01 00:00:00

abstract：:Although physiologic modeling has not gained the widespread acceptance that was originally projected, it may serve as the basis for future PK/PD modeling approaches. In addition, with more effort applied to developing in vitro and animal-to-human predictions, physiologic modeling may assume a higher position in the ph...

journal_title：Journal of clinical pharmacology

authors： Colburn WA

更新日期：1988-08-01 00:00:00

abstract：:The bioavailability and pharmacokinetics of dilevalol following oral and intravenous administration were investigated in 12 healthy male volunteers. Dilevalol HCl was administered as a 200-mg oral tablet and a 50-mg intravenous infusion using a randomized cross-over design. Blood and urine samples were collected over ...

journal_title：Journal of clinical pharmacology

authors： Kramer WG,Nagabhushan N,Affrime MB,Perentesis GP,Symchowicz S,Patrick JE

更新日期：1988-07-01 00:00:00

abstract：:This study assesses the magnitude and duration of action of three different oral doses of the new orally active angiotensin-converting enzyme (ACE) inhibitor RO 312848 (cilazapril, Hoffman-LaRoche, Nutley, NJ) on blood pressure and plasma ACE levels. Twelve hypertensive patients were separated into two groups: Group A...

journal_title：Journal of clinical pharmacology

authors： Mulinari RA,Gouni I,Gavras I,Gavras H

更新日期：1988-07-01 00:00:00

abstract：:This study outlines the attempts of four states (Louisiana, Kansas, Wisconsin, and Michigan) to restrict anorectic prescriptions. The actions in these four states exemplify the various mechanisms used in regulating anorectics, ranging from educational efforts to legislative enactments. We examine the evidence used in ...

journal_title：Journal of clinical pharmacology

authors： Richard BW,Lasagna L

更新日期：1988-05-01 00:00:00

abstract：:The effect of 6% hydroxyethyl starch (hetastarch) and 5% human serum albumin (albumin) infusion on coagulation in 12 patients with septic shock was evaluated. Patients were randomly assigned to receive either albumin (N = 6) or hetastarch (N = 6) infusion over a 24-hour study interval. The prothrombin time (PT), parti...

journal_title：Journal of clinical pharmacology

authors： Falk JL,Rackow EC,Astiz ME,Weil MH

更新日期：1988-05-01 00:00:00

abstract：:Acebutolol, a beta-1 selective beta blocker with intrinsic sympathomimetic activity has been shown to be an effective agent in chronic angina pectoris therapy, with twice or three times daily dosing. The long-term effects of 400 mg of acebutolol given only once a day versus placebo on exercise hemodynamics, ST segment...

journal_title：Journal of clinical pharmacology

authors： Piña IL,Smith EV,Weidler DJ

更新日期：1988-05-01 00:00:00

abstract：:Twenty young (45 years or younger) and 20 older (55 years or older) adult patients with mild hypertension were enrolled in this study to compare the hemodynamic effects of labetalol versus placebo in two age groups. Ten patients in each group were randomly assigned to receive either a single oral dose of labetalol (20...

journal_title：Journal of clinical pharmacology

authors： Buell JC,Eliot RS,Plachetka JR,Little MR

更新日期：1988-04-01 00:00:00

abstract：:The interactive effects of the coadministration of steady-state cimetidine and single-dose pentopril, an angiotensin converting enzyme inhibitor, on the pharmacokinetic disposition of each other were studied in humans. Cimetidine reduced the clearance of pentopril by 11 to 14%. This reduction in clearance was shown to...

journal_title：Journal of clinical pharmacology

authors： Kochak GM,Rakhit A,Thompson TN,Hurley ME

更新日期：1988-03-01 00:00:00

abstract：:A total of 175 physicians were surveyed by questionnaire before a Clinical Pharmacology Consult Service was started. Of those that responded, 72% thought the service would be helpful, although 40% said they would use the service no more than once a month. Most physicians (75%) preferred self-initiated consultations to...

journal_title：Journal of clinical pharmacology

authors： Casner PR,Dillon KR

更新日期：1988-01-01 00:00:00

abstract：:The pharmacokinetics of codeine, codeine glucuronide, morphine, and morphine glucuronide were assessed after single- (60 mg) and multiple-dose (60 mg every six hours for nine doses) oral administration of codeine sulfate to six normal volunteers. Multiple blood and urine samples were collected after administration of ...

journal_title：Journal of clinical pharmacology

authors： Guay DR,Awni WM,Halstenson CE,Findlay JW,Opsahl JA,Abraham PA,Jones EC,Matzke GR

更新日期：1987-12-01 00:00:00

abstract：:Esmolol is an intravenous beta blocker with a short duration of action. The pharmacokinetics of esmolol and its acid metabolite, ASL-8123, were studied in nine patients who had stable, biopsy-proved Laennec's cirrhosis and in three normal volunteer controls. Kinetics were determined after a four-hour continuous infusi...

journal_title：Journal of clinical pharmacology

authors： Buchi KN,Rollins DE,Tolman KG,Achari R,Drissel D,Hulse JD

更新日期：1987-11-01 00:00:00

abstract：:The pharmacokinetics of enoximone and its sulfoxide metabolite were determined following administration of a single oral dose of 1 or 2 mg/kg in seven patients with congestive heart failure, and in two normal volunteers following a single 75-mg capsule, and were compared to those published previously. Plasma concentra...

journal_title：Journal of clinical pharmacology

authors： Lima JJ,Leier CV,Holtz L,Sterechele J,Shields BJ,MacKichan JJ

更新日期：1987-09-01 00:00:00

abstract：:Calcium channel blocker therapy has proved protective in certain models of ischemic-induced acute renal failure. This effect may be related to the prevention of calcium influx into injured cells or by the vasodilatory effects of verapamil that may result in an improvement in renal blood flow. In the current study, the...

journal_title：Journal of clinical pharmacology

authors： Watson AJ,Gimenez LF,Klassen DK,Stout RL,Whelton A

更新日期：1987-08-01 00:00:00

abstract：:The short-term effect of the blockade of the beta-adrenergic receptors on serum lipoproteins and the plasma activities of the enzymes involved in the metabolism of the serum lipoproteins: lipoprotein lipase (LPL), hepatic lipase (HL) and lecithin: cholesterol acyltransferase (LCAT) was evaluated in ten healthy normoli...

journal_title：Journal of clinical pharmacology

authors： Harvengt C,Heller FR,Martiat P,Van Nieuwenhuyze Y

更新日期：1987-07-01 00:00:00

abstract：:The safety and efficacy of step-one therapy with enalapril, a new angiotensin-converting enzyme inhibitor, and metoprolol were compared in a double-blind, multicenter study involving 150 patients who had mild to moderate essential hypertension. After a four-week period of placebo run-in, therapy was initiated with twi...

journal_title：Journal of clinical pharmacology

authors： Nugent LW,Miola SR,Walker JF

更新日期：1987-07-01 00:00:00

abstract：:Azlocillin is an important acylureido penicillin antibiotic for the management of complex gram-negative infections particularly those caused by Pseudomonas species. The current studies demonstrate that it manifests dose-dependent pharmacokinetics during the usual regimens of clinical dosing, that enterohepatic recircu...

journal_title：Journal of clinical pharmacology

authors： Whelton A,Stout RL,Spilman PS,Delgado FA,Watson AJ

更新日期：1987-07-01 00:00:00

abstract：:The antihypertensive effect of enalaprilat (MK-422), an intravenous (IV), nonsulfhydryl converting-enzyme inhibitor, was evaluated in a double-blind study of 14 patients with mild to moderate hypertension. The seven patients in the treatment group initially received IV enalaprilat 1.25 mg q6h for 24 hours. Thereafter,...

journal_title：Journal of clinical pharmacology

authors： Evans RR,Henzler MA,Weber EM,DiPette DJ

更新日期：1987-05-01 00:00:00